Publications

2025

Intestinal epithelial PTPN23 is essential for gut barrier integrity and prevention of fatal bacterial translocation.

Sanchez Alvarez R, Montalban-Arques A, Morsy Y, Gottier C, Häfliger J, Atrott K, Bircher A, Katkeviciute E, Pöhlmann D, Linzmeier L, Determann M, Mamie C, Niechcial A, Schwarzfischer M, Zeissig S, Lang S, Scharl M, Spalinger M.

J Crohns Colitis. 2025

Synthetic GPR84 Agonists in Colorectal Cancer: Effective in THP-1 Cells but Ineffective in BMDMs and MC38 Mouse Tumor Models.

Schwarzfischer M, Walker MR, Curcio M, Boshta NM, Marchand A, Soons E, Pöhlmann D, Wawrzyniak M, Morsy Y, Lang S, Spalinger MR, Versele M, Scharl M.

Int J Mol Sci. 2025

Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene.

Spalinger MR, Sanati G, Chatterjee P, Hai R, Li J, Santos AN, Nordgren TM, Tremblay ML, Eckmann L, Hanson E, Scharl M, Wu X, Boland BS, McCole DF.

Cell Mol Gastroenterol Hepatol. 2025

2024

Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses.

Chatterjee P, Spalinger MR, Acevedo C, Gries CM, Manz SM, Canale V, Santos AN, Shawki A, Sayoc-Becerra A, Lei H, Crawford MS, Eckmann L, Borneman J, McCole DF.

bioRxiv [Preprint]. 2024

Impact of Nanoplastic Particles on Macrophage Inflammation and Intestinal Health in a Mouse Model of Inflammatory Bowel Disease.

Schwarzfischer M, Ruoss TS, Niechcial A, Lee SS, Wawrzyniak M, Laimbacher A, Atrott K, Manzini R, Wilmink M, Linzmeier L, Morsy Y, Lang S, Rogler G, Kaegi R, Scharl M, Spalinger MR.

Nanomaterials (Basel). 2024

Microbiota Manipulation as an Emerging Concept in Cancer Therapy.

Spalinger MR, Scharl M.

Visc Med. 2024

2023

Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis.

Niechcial A, Schwarzfischer M, Wawrzyniak M, Atrott K, Laimbacher A, Morsy Y, Katkeviciute E, Häfliger J, Westermann P, Akdis CA, Scharl M, Spalinger MR.

J Crohns Colitis. 2023

SKAP2-A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function.

Wilmink M, Spalinger MR.

Biomedicines. 2023

Evaluation of the effect of tramadol, paracetamol and metamizole on the severity of experimental colitis.

Spalinger M, Schwarzfischer M, Niechcial A, Atrott K, Laimbacher A, Jirkof P, Scharl M.

Lab Anim. 2023

Temperature-triggered in situ forming lipid mesophase gel for local treatment of ulcerative colitis.

Carone M, Spalinger MR, Gaultney RA, Mezzenga R, Hlavačková K, Mookhoek A, Krebs P, Rogler G, Luciani P, Aleandri S.

Nat Commun. 2023

TiO2 nanoparticles abrogate the protective effect of the Crohn's disease-associated variation within the PTPN22 gene locus.

Schwarzfischer M, Niechcial A, Handler K, Morsy Y, Wawrzyniak M, Laimbacher AS, Atrott K, Manzini R, Baebler K, Hering L, Katkeviciutė E, Häfliger J, Lang S, Keller ME, Woodtli J, Eisenbeiss L, Kraemer T, Schraner EM, Wiesendanger M, Zeissig S, Rogler G, Moor AE, Scharl M, Spalinger MR.

Gut. 2023

PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection.

Spalinger MR, Canale V, Becerra A, Shawki A, Crawford M, Santos AN, Chatterjee P, Li J, Nair MG, McCole DF.

JCI Insight. 2023

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.J

Clin Invest. 2023

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.

Canale V, Spalinger MR, Alvarez R, Sayoc-Becerra A, Sanati G, Manz S, Chatterjee P, Santos AN, Lei H, Jahng S, Chu T, Shawki A, Hanson E, Eckmann L, Ouellette AJ, McCole DF.

Cell Mol Gastroenterol Hepatol. 2023

Co-cultivation is a powerful approach to produce a robust functionally designed synthetic consortium as a live biotherapeutic product (LBP).

Kurt F, Leventhal GE, Spalinger MR, Anthamatten L, Rogalla von Bieberstein P, Menzi C, Reichlin M, Meola M, Rosenthal F, Rogler G, Lacroix C, de Wouters T.

Gut Microbes. 2023

Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity.

Häfliger J, Schwarzfischer M, Atrott K, Stanzel C, Morsy Y, Wawrzyniak M, Lang S, Valenta T, Basler K, Rogler G, Scharl M, Spalinger MR.

Cell Mol Gastroenterol Hepatol. 2023

2022

Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer.

Busenhart P, Montalban-Arques A, Katkeviciute E, Morsy Y, Van Passen C, Hering L, Atrott K, Lang S, Garzon JFG, Naschberger E, Hartmann A, Rogler G, Stürzl M, Spalinger MR, Scharl M.

J Immunother Cancer. 2022

Ingested nano- and microsized polystyrene particles surpass the intestinal barrier and accumulate in the body.

Schwarzfischer M, Niechcial A, Lee SS, Sinnet B, Wawrzyniak M, Laimbacher A, Atrott K, Manzini R, Morsy Y, Häfliger J, Lang S, Rogler G, Kaegi R, Scharl M, Spalinger MR.

NanoImpact. 2022

Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.

Spalinger MR, Crawford M, Bobardt SD, Li J, Sayoc-Becerra A, Santos AN, Shawki A, Chatterjee P, Nair MG, McCole DF.

Mucosal Immunol. 2022

Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence.

Spalinger MR, Shawki A, Chatterjee P, Canale V, Santos A, Sayoc-Becerra A, Scharl M, Tremblay ML, Borneman J, McCole DF.

Gut. 2022

2021

Loss of PTPN22 Promotes Intestinal Inflammation by Compromising Granulocyte-mediated Antibacterial Defence.

Spalinger MR, Schwarzfischer M, Niechcial A, Atrott K, Laimbacher A, Gottier C, Lang S, Scharl M.J

Crohns Colitis. 2021

Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development.

Haftmann C, Zwicky P, Ingelfinger F, Mair F, Floess S, Riedel R, Durek P, Spalinger MR, Friebel E, Leung BP, Lutz M, Puertas N, Amorim A, Schärli S, Becher B, Kisielow J, Waisman A, Mashreghi MF, Huehn J, Becher B.

Sci Immunol. 2021

Combination of Vedolizumab With Tacrolimus Is More Efficient Than Vedolizumab Alone in the Treatment of Experimental Colitis.

Manzini R, Schwarzfischer M, Atrott K, Laimbacher A, Lang S, Wawrzyniak M, Rickenbacher A, Turina M, Hruz P, Lissner D, Siegmund B, Rogler G, Scharl M, Spalinger MR.

Inflamm Bowel Dis. 2021

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR.

J Exp Med. 2021

Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.

Montalban-Arques A, Katkeviciute E, Busenhart P, Bircher A, Wirbel J, Zeller G, Morsy Y, Borsig L, Glaus Garzon JF, Müller A, Arnold IC, Artola-Boran M, Krauthammer M, Sintsova A, Zamboni N, Leventhal GE, Berchtold L, de Wouters T, Rogler G, Baebler K, Schwarzfischer M, Hering L, Olivares-Rivas I, Atrott K, Gottier C, Lang S, Boyman O, Fritsch R, Manz MG, Spalinger MR, Scharl M.

Cell Host Microbe. 2021

A Novel OGR1 (GPR68) Inhibitor Attenuates Inflammation in Murine Models of Colitis.

de Vallière C, Bäbler K, Busenhart P, Schwarzfischer M, Maeyashiki C, Schuler C, Atrott K, Lang S, Spalinger MR, Scharl M, Ruiz-Castro PA, Hausmann M, Rogler G.

Inflamm Intest Dis. 2021

T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.

Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF.

J Clin Invest. 2021

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.

Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs JB, Wawrzyniak M, Atrott K, van de Sande M, Lang S, Becher B, Rogler G, Scharl M, Spalinger MR.

Int J Mol Sci. 2021

Energy Drink Administration Ameliorates Intestinal Epithelial Barrier Defects and Reduces Acute DSS Colitis.

Manzini R, Schwarzfischer M, Bircher A, Niechcial A, Vavricka SR, Atrott K, Lang S, Scharl M, Spalinger MR.

Inflamm Bowel Dis. 2021

Contribution of CD3+CD8- and CD3+CD8+ T Cells to TNF-α Overexpression in Crohn Disease-Associated Perianal Fistulas and Induction of Epithelial-Mesenchymal Transition in HT-29 Cells.

Bruckner RS, Spalinger MR, Barnhoorn MC, Feakins R, Fuerst A, Jehle EC, Rickenbacher A, Turina M, Niechcial A, Lang S, Hawinkels LJAC, van der Meulen-de Jong AE, Verspaget HW, Rogler G, Scharl M.

Inflamm Bowel Dis. 2021

The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions.

Spalinger MR, Sayoc-Becerra A, Ordookhanian C, Canale V, Santos AN, King SJ, Krishnan M, Nair MG, Scharl M, McCole DF.

J Crohns Colitis. 2021

Diet and Inflammatory Bowel Disease: What Quality Standards Should Be Applied in Clinical and Laboratory Studies?

Rogler G, Scharl M, Spalinger M, Yilmaz B, Zaugg M, Hersberger M, Schreiner P, Biedermann L, Herfarth H.

Mol Nutr Food Res. 2021

Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development.

Katkeviciute E, Hering L, Montalban-Arques A, Busenhart P, Schwarzfischer M, Manzini R, Conde J, Atrott K, Lang S, Rogler G, Naschberger E, Schellerer VS, Stürzl M, Rickenbacher A, Turina M, Weber A, Leibl S, Leventhal GE, Levesque M, Boyman O, Scharl M, Spalinger MR.

J Clin Invest. 2021

Protein Tyrosine Phosphatase Nonreceptor Type 2 Expression Does Not Correlate with Viral Load or Response to Direct-Acting Antiviral Therapy in Hepatitis C Virus Infections-Infected Patients.

Sabev M, Blümel S, Lang S, Gottier C, Weber A, Mertens J, Müllhaupt B, Scharl M, Spalinger MR.

Digestion. 2021

2020

PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.

Spalinger MR, Sayoc-Becerra A, Santos AN, Shawki A, Canale V, Krishnan M, Niechcial A, Obialo N, Scharl M, Li J, Nair MG, McCole DF.

Gastroenterology. 2020

The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli.

Shawki A, Ramirez R, Spalinger MR, Ruegger PM, Sayoc-Becerra A, Santos AN, Chatterjee P, Canale V, Mitchell JD, Macbeth JC, Gries CM, Tremblay ML, Hsiao A, Borneman J, McCole DF.

Gut Microbes. 2020

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.

Hering L, Katkeviciute E, Schwarzfischer M, Busenhart P, Gottier C, Mrdjen D, Komuczki J, Wawrzyniak M, Lang S, Atrott K, Becher B, Rogler G, Scharl M, Spalinger MR.

Front Immunol. 2020

The Role of Protein Tyrosine Phosphatases in Inflammasome Activation.

Spalinger MR, Schwarzfischer M, Scharl M.

Int J Mol Sci. 2020

Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine.

Niechcial A, Butter M, Manz S, Obialo N, Bäbler K, van der Lely L, Lang S, Gottier C, McCole DF, Scharl M, Spalinger MR.

Inflamm Bowel Dis. 2020

2019

Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.

Spalinger MR, Schwarzfischer M, Hering L, Shawki A, Sayoc A, Santos A, Gottier C, Lang S, Bäbler K, Geirnaert A, Lacroix C, Leventhal GE, Dai X, Rawlings D, Chan AA, Rogler G, McCole DF, Scharl M.

Mucosal Immunol. 2019

Loss of PTPN23 Promotes Proliferation and Epithelial-to-Mesenchymal Transition in Human Intestinal Cancer Cells.

van der Lely L, Häfliger J, Montalban-Arques A, Bäbler K, Schwarzfischer M, Sabev M, Gottier C, Lang S, Scharl M, Spalinger MR.

Inflamm Intest Dis. 2019

β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.

Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M.

Int J Cancer. 2019

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis.

Raselli T, Hearn T, Wyss A, Atrott K, Peter A, Frey-Wagner I, Spalinger MR, Maggio EM, Sailer AW, Schmitt J, Schreiner P, Moncsek A, Mertens J, Scharl M, Griffiths WJ, Bueter M, Geier A, Rogler G, Wang Y, Misselwitz B.

J Lipid Res. 2019

Stepwise Development of an in vitro Continuous Fermentation Model for the Murine Caecal Microbiota.

Poeker SA, Lacroix C, de Wouters T, Spalinger MR, Scharl M, Geirnaert A.

Front Microbiol. 2019

Administration of the Hyper-immune Bovine Colostrum Extract IMM-124E Ameliorates Experimental Murine Colitis.

Spalinger MR, Atrott K, Baebler K, Schwarzfischer M, Melhem H, Peres DR, Lalazar G, Rogler G, Scharl M, Frey-Wagner I.

J Crohns Colitis. 2019

Transplantation of Human Intestine Into the Mouse: A Novel Platform for Study of Inflammatory Enterocutaneous Fistulas.

Bruckner RS, Nissim-Eliraz E, Marsiano N, Nir E, Shemesh H, Leutenegger M, Gottier C, Lang S, Spalinger MR, Leibl S, Rogler G, Yagel S, Scharl M, Shpigel NY.

J Crohns Colitis. 2019

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.

Spalinger MR, Schmidt TS, Schwarzfischer M, Hering L, Atrott K, Lang S, Gottier C, Geirnaert A, Lacroix C, Dai X, Rawlings DJ, Chan AC, von Mering C, Rogler G, Scharl M.

J Clin Invest. 2019

Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23.

Ulugöl S, Hering L, Manzini R, Montalban Arques A, Gottier C, Lang S, Scharl M, Spalinger MR.

Inflamm Intest Dis. 2019

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.

Wyss A, Raselli T, Perkins N, Ruiz F, Schmelczer G, Klinke G, Moncsek A, Roth R, Spalinger MR, Hering L, Atrott K, Lang S, Frey-Wagner I, Mertens JC, Scharl M, Sailer AW, Pabst O, Hersberger M, Pot C, Rogler G, Misselwitz B.

Mucosal Immunol. 2019

Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease.

Tcymbarevich I, Richards SM, Russo G, Kühn-Georgijevic J, Cosin-Roger J, Baebler K, Lang S, Bengs S, Atrott K, Bettoni C, Gruber S, Frey-Wagner I, Scharl M, Misselwitz B, Wagner CA, Seuwen K, Rogler G, Ruiz PA, Spalinger M, de Vallière C.

J Crohns Colitis. 2019

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

Tcymbarevich IV, Eloranta JJ, Rossel JB, Obialo N, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick GA, Wagner CA, Scharl M, Seuwen K, Ruiz PA, Rogler G, de Vallière C, Misselwitz B; Swiss IBD Cohort Study Group.

BMC Gastroenterol. 2019

2018

The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.

Yilmaz B, Spalinger MR, Biedermann L, Franc Y, Fournier N, Rossel JB, Juillerat P, Rogler G, Macpherson AJ, Scharl M.

PLoS One. 2018

Eribulin Does Not Prevent Epithelial-to-Mesenchymal Transition in HT-29 Intestinal Epithelial Cells.

Leutenegger M, Bruckner R, Spalinger MR, Lang S, Rogler G, Scharl M.

Inflamm Intest Dis. 2018

PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation.

Spalinger MR, Scharl M.

Mol Cell Oncol. 2018

Mono Sodium Urate Crystal-induced Peritonitis for in vivoAssessment of Inflammasome Activation.

Spalinger MR, Scharl M.

Bio Protoc. 2018

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

Cosin-Roger J, Spalinger MR, Ruiz PA, Stanzel C, Terhalle A, Wolfram L, Melhem H, Atrott K, Lang S, Frey-Wagner I, Fried M, Scharl M, Hausmann M, Rogler G.

PLoS One. 2018

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.

Spalinger MR, Manzini R, Hering L, Riggs JB, Gottier C, Lang S, Atrott K, Fettelschoss A, Olomski F, Kündig TM, Fried M, McCole DF, Rogler G, Scharl M.

Cell Rep. 2018

2017

Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases.

Fagagnini S, Heinrich H, Rossel JB, Biedermann L, Frei P, Zeitz J, Spalinger M, Battegay E, Zimmerli L, Vavricka SR, Rogler G, Scharl M, Misselwitz B.

PLoS One. 2017

Gastroresistant oral peptide for fluorescence imaging of colonic inflammation.

Luciani P, Estella-Hermoso de Mendoza A, Casalini T, Lang S, Atrott K, Spalinger MR, Pratsinis A, Sobek J, Frey-Wagner I, Schumacher J, Leroux JC, Rogler G.

J Control Release. 2017

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.

Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M.

Autophagy. 2017

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.

Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA.

Nat Commun. 2017

Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms.

Melhem H, Spalinger MR, Cosin-Roger J, Atrott K, Lang S, Wojtal KA, Vavricka SR, Rogler G, Frey-Wagner I.

J Crohns Colitis. 2017

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome.

Ruiz PA, Morón B, Becker HM, Lang S, Atrott K, Spalinger MR, Scharl M, Wojtal KA, Fischbeck-Terhalle A, Frey-Wagner I, Hausmann M, Kraemer T, Rogler G.

Gut. 2017

2016

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.

Spalinger MR, Zeitz J, Biedermann L, Rossel JB, Sulz MC, Frei P, Scharl S, Vavricka SR, Fried M, Rogler G, Scharl M; Swiss IBD Cohort Study Group.

PLoS One. 2016

The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis.

Spalinger MR, Scharl M.

United European Gastroenterol J. 2016

Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis.

Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M.

PLoS One. 2016

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

J Clin Invest. 2016

Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.

Spalinger MR, McCole DF, Rogler G, Scharl M.

World J Gastroenterol. 2016

Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.

Kasper SH, Spalinger MR, Leonardi I, Gerstgrasser A, Raselli T, Gottier C, Atrott K, Frey-Wagner I, Fischbeck-Terhalle A, Rogler G, Scharl M.

Digestion. 2016

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.

Spalinger MR, Voegelin M, Biedermann L, Zeitz J, Rossel JB, Sulz MC, Frei P, Scharl S, Vavricka SR, Fried M, Rogler G, Scharl M; Swiss IBD Cohort Study Group.

Digestion. 2016

2015

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.

de Vallière C, Wang Y, Eloranta JJ, Vidal S, Clay I, Spalinger MR, Tcymbarevich I, Terhalle A, Ludwig MG, Suply T, Fried M, Kullak-Ublick GA, Frey-Wagner I, Scharl M, Seuwen K, Wagner CA, Rogler G.

Inflamm Bowel Dis. 2015

Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.

Spalinger MR, McCole DF, Rogler G, Scharl M.

Inflamm Bowel Dis. 2015

A cell type-specific role of protein tyrosine phosphatase non-receptor type 2 in regulating ER stress signalling.

Kasper SH, Spalinger MR, Raselli T, Scharl M.

Digestion. 2015

2014

A distinct pattern of disease-associated single nucleotide polymorphisms in IBD risk genes in a family with Crohn's disease.

Barthel C, Spalinger MR, Brunner J, Lang S, Fried M, Rogler G, Scharl M.

Eur J Gastroenterol Hepatol. 2014

Bilberry-derived anthocyanins prevent IFN-γ-induced pro-inflammatory signalling and cytokine secretion in human THP-1 monocytic cells.