Welcome to the Spalinger Lab

Research Overview

Endometrium Conditions and Benign Endometrial Diseases.

Benign endometrial diseases encompass a group of non-cancerous medical conditions that affect the endometrium. These conditions can cause a range of symptoms and health issues, and while they are not cancerous, they significantly impact women's quality of life and reproductive health.

Our main areas of research include:

Endometriosis: Affecting up to 10% of reproductive-age women worldwide, endometriosis involves the presence of endometrial-like tissue at ectopic sites (i.e. outside the uterine cavity). Ectopically growing tissue causes pain, inflammation, and the formation of adhesions and scar tissue. Pelvic pain, painful periods, and fertility problems are the main consequences and significantly contribute to disease morbidity.

Adenomyosis is characterized by the growth of endometrial tissue into the muscular wall of the uterus. This condition can cause heavy menstrual bleeding, pain, and enlargement of the uterus.

Chronic Endometritis is characterized by a chronic inflammation of the endometrial lining. Triggered by infections or immune system disorders, it can cause abnormal bleeding and infertility.

Our research group combines molecular biology, immunology, and NGS technologies to gather a better understanding of endometrial conditions and the pathological mechanisms leading to disease manifestation. Our ultimate goal is the development of novel therapeutic solutions and improved diagnostic tools for endometrial diseases, which will promote the heath of millions of women worldwide affected by endometrial disorders.

Check out our:

Team members

Group Leader

Publication List